On Super Bowl Sunday can we expect Tom Brady and the Patriots to stay perfect and make NFL history?

“This could be the biggest-bet game ever,” predicts Chuck Esposito, assistant vice president of race and sports book operations at Caesars Palace in Las Vegas.

The New England Patriots are favored by 12 points over the New York Giants, but something to consider is that the Pats have failed to cover the point spread in two playoff games. Eli Manning and the Giants, on the other hand, managed to beat the spread in three playoff games.

So what are some of the online sports books saying?

“We expect that Super Bowl 42 in Arizona will be the most bet Super Bowl of all time,” stated Point-Spreads.com Publisher Thomas Jensen. “New York has a strong base of gamblers rooting for the Giants and all those New England fans will not miss a chance to bet on their Patriots going 19-0. We are urging our readers to get their bets in early this year.”

And over at Bodoglife.com they’re suggesting you keep an eye on Tom Brady and his new boot (one seems larger than the other and looks suspiciously like a cast) and some of the other Super Bowl prop bets that are being offered (such as will Eli Manning’s big bro Peyton show up?).

The underdog New York Giants are vying for the Super Bowl championship and the Lombardi Trophy this Sunday against the 12.5 favorites the New England Patriots. A win by the Giants would make them the second team in the history of the NFl to win all their playoff games on the road. But while Giants fans are eager to see Eli Manning and the Giants win this one for New York, Vegas sports books are hoping for a Patriots victory.

Right now bettors are backing the Giants by a margin of 3-1 largely due to the 12.5 spread favoring New England. But anything less than 12.5 will still spell a “win” for wagers placed on the Giants. That’s a huge spread considering that underdogs with at least +7 points tend to win.

“Las Vegas is definitely cheering for the Patriots right now,” Jason McCormick, director of the sports book at Red Rock Casino in Las Vegas told NYPost.com today. If the Giants win, “It wouldn’t be a particularly good result.”

Of course, Vegas and online sports books are hoping to take an equal amount of wagers for both sides. The volume of wagers in support of the Pats will likely increase by Friday through Sunday as kickoff time approaches. By that time, they’ll have more information on the condition of Tom Brady’s injured ankle McCormick said.

“The Tom Brady situation definitely has a heavy influence in betting on the Patriots,” McCormick said. “If you’re looking to back the Patriots, there no sense playing it right now, until you have all the information.”

The fact that the Patriots are aiming to become the NFL’s first 19-0 team should cause more people to tune in and bet on the big game. Last year Nevada handled $93 million in action on the Indianapolis Colts vs. Chicago Bears matchup, but industry analysts expect that number to top the $100 million-dollar mark for this year’s historical game.

A few Super Bowl betting tips to keep in mind:

- Look at the entire season for both teams
- Check the matchup reports
- Bet the underdog
- Bet the “Under”
- Watch your wallet. Aside from typical bets, there are so many fun proposition bets to wager on.